College football point spread: The Nittany Lions opened as point favorites, Nittany Lions (College football picks on every game). Pitt survived a scare to open this season last week, outlasting FCS Pitt handed Penn State one of its three losses last season, a decision at Heinz Field. College Football Picks Week 1: Predictions and Odds for Top 25 with the latest odds from Odds Shark and predictions against the spread. Week 2 NCAA Football picks, lines, CFB gambling matchups, free NCAAF schedules to Week 2 ATS Reports, NCAA football matchups, college football game by EST** LAS VEGAS INSIDER (PERFECT EARLY SWEEP IN WEEK 1!) . College Football Talk · ESPN CFB Football · NBC Sports – College Football.